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Archive for the ‘adolescents’ Category

Fighting the ‘Fatso Gene’ by Exercising for an Hour a Day

Friday, August 13th, 2010

It is not news that exercise and eating healthy can help to combat obesity. Additonally, according to lead author Jonatan Ruiz of the Karolinska Institute in Sweden, in a new European Study, one hour of moderate to vigorous exercise a day can help teenagers beat the effects of a common obesity related gene. The study appears in the April edition of Archives of Pediatrics and Adolescent Medicine. According to another study’s lead author, Evadnie Rampersaud of the University of Miami, and co-author, Dr. Alan Shuldiner of the University of Maryland, who studied Amish adults said the new findings are “very interesting” because they suggest one hour daily spent exercising can be enough for teenagers at risk. University of Miami researchers now are studying adults in an employee wellness program to see what it takes for them to overcome the fatso gene, Rampersaud said.

By CARLA K. JOHNSON
The Associated Press
Monday, April 5, 2010; 4:33 PM

CHICAGO — One hour of moderate to vigorous exercise a day can help teens beat the effects of a common obesity-related gene with the nickname “fatso,” according to a new European study.

The message for adolescents is to get moving, said lead author Jonatan Ruiz of the Karolinska Institute in Sweden.

“Be active in your way,” Ruiz said. “Activities such as playing sports are just fine and enough.”

The study, released Monday, appears in the April edition of Archives of Pediatrics and Adolescent Medicine.

The research supports U.S. guidelines that tell children and teenagers to get an hour or more of physical activity daily, most of it aerobic activity such as running, jumping rope, swimming, dancing and bicycling.

Scientists are finding evidence that both lifestyle and genes cause obesity and they’re just learning how much diet and exercise can offset the inherited risk.

One gene involved with obesity, the FTO gene, packs on the pounds when it shows up in a variant form. Adults who carry two copies of the gene variant – about 1 in 6 people – weigh on average 7 pounds more than people who don’t.

In the new study, 752 teenagers, who had their blood tested for the gene variant, wore monitoring devices for a week during waking hours to measure their physical activity.

Exercising an hour or more daily made a big difference for the teens who were genetically predisposed to obesity. Their waist measurements, body mass index scores and body fat were the same, on average, as the other teenagers with regular genes.

But the teens with the gene variant had more body fat, bigger waists and higher BMI if they got less than an hour of exercise daily. The results were similar for boys and girls.

The teens lived in Greece, Germany, Belgium, France, Hungary, Italy, Sweden, Austria and Spain. The study was funded by the Spanish and Swedish governments and the European Union.

The new study found that most of the teenagers had at least one copy of the variant gene. Only 37 percent had regular genes. The rest had either one of two copies of the pesky fatso gene.

An earlier study in Amish adults in Lancaster County, Pa., found they needed three to four hours of moderate activity daily to beat the gene. The adults in that study did things like brisk walking, housecleaning and gardening.

The teens in the new study may have exercised more vigorously than the Amish adults, Ruiz said. The new analysis was designed to see whether the current U.S. guidelines – which specify a moderate to vigorous level of exercise for an hour a day – made a difference for kids.

The lead author of the Amish study, Evadnie Rampersaud of the University of Miami, said the new findings are “very interesting” because they suggest one hour daily spent exercising can be enough for teenagers at risk.

University of Miami researchers now are studying adults in an employee wellness program to see what it takes for them to overcome the fatso gene, Rampersaud said.

“The message is clear: genes are not destiny,” said Dr. Alan Shuldiner of the University of Maryland, a co-author of the Amish study. “Those with obesity susceptibility genes should be especially motivated to engage in a physically active lifestyle.”

Obesity in Infants Can Be Diagnosed at 6 Months

Friday, August 13th, 2010

Should we take this leap? Should we make this diagnosis? Well this is the same question people have been asking for quite some time about a relevant and concerning issue. Some groundbreaking new research indicates that obesity can be diagnosed earlier than we have ever imagined.  This study was published by researchers at the University of Texas Medical Branch at Galveston in Pediatrics.  Dr. David McCormick, UTMB clinical professor of pediatrics and senior author of the study, stated that clinicians have not really been focusing on obesity in infants and the longstanding effects of it. This finding brings attention to the possibility of preventing obesity via earlier identification of the problem.

ScienceDaily (Apr. 7, 2010) — Obesity can be detected in infants as young as 6 months, according to a new study by researchers at the University of Texas Medical Branch at Galveston.

By analyzing the electronic medical records of babies seen for routine “well-child” visits to the UTMB pediatric clinic, the investigators found that about 16 percent of 6-month-olds fit the study’s criterion for obesity — a weight-for-length ratio that put them in the top 5 percent of all babies in their age group. (Weight for length was used instead of the conventional body mass index because BMI is based on weight and height as measured while standing, which neither 6-month-olds nor 24-month-olds can do well enough to measure.) Further analysis of the records indicated that obese 2-year-olds were much more likely to have been obese at 6 months than 2-year-olds who were not obese.

The obese babies’ medical records rarely showed that clinicians had addressed the issue at either 6-month or 24-month visits, despite a well-established connection between obesity at a young age and obesity later in life, which is linked to such serious health problems as diabetes, heart disease and high blood pressure.

“Until very recently, pediatricians really haven’t been focusing on obesity in babies,” said Dr. David McCormick, UTMB clinical professor of pediatrics and senior author of the study, “Infant Obesity: Are We Ready to Make this Diagnosis?” which is now online in the Journal of Pediatrics. “We’re just getting a handle on it descriptively right now. What we’re hoping to do is alert our colleagues and our parents. If we address weight management through nutrition and exercise as early in life as possible, it’s going to work a lot better.”

According to McCormick, pediatricians confronting infant obesity can recommend a number of measures that other research has shown are linked to healthy weight, measures that should be particularly effective because babies’ mothers have much more control over their diets than mothers of older children do.

“Studies have shown that exclusive breastfeeding — breastfeeding alone, not breastfeeding combined with bottle-feeding — prevents obesity,” McCormick said. “Getting enough fiber — eating apples instead of drinking apple juice, for example — also helps keep babies on track to a healthy weight. By contrast, improper early introduction of cereal by adding it to an infant’s bottle promotes obesity.”

McCormick observed that maternal data collected in his group’s investigation matched well with other studies of children and adolescents that showed higher odds of obesity among boys and girls whose mothers were already obese before becoming pregnant or who gained an excessive amount of weight during pregnancy. Such results, he said, added even more urgency to the need to deal with childhood weight issues effectively and address what could be a multigenerational cycle of obesity.

“We need to do a lot better as clinicians and educators at getting our community educated and working through the entire age spectrum, because babies who are overweight are more likely to be overweight children and adolescents, and then later, when obese women are ready to have a family, their babies are more likely to become obese,” McCormick said. “We need to deal with this through all ages and through pregnancy, because if a woman is already overweight when she becomes pregnant, it’s extremely difficult for her to do anything about her weight at that point.”

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